Oral Health
Omega-3 May Combat Mouth Bacteria, Boost Oral Health...
Reports a New Study From The University of Kentucky.
In addition to Omega 3 fish- derived nutritional lipids-oils being beneficial for cardiovascular, bone & joint health, now dental health benefits of omega-3 fatty acids may include anti-bacterial effects, extending the benefits beyond inflammation, says a new study from the University of Kentucky.
Omega-3 fatty acids of marine and plant origin were found to have strong anti-bacterial activity against a range of oral pathogens, according to findings published in Molecular Oral Microbiology.
EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and ALA (alpha-linolenic acid), as well as their naturally-occurring fatty acid ethyl esters could inhibit the growth of oral pathogens, including Streptococcus mutans, Candida albicans, and Porphyromonas ginigivalis at relatively low doses.
"To date, this is the first study to demonstrate the significant antibacterial activity of omega-3 fatty acids and their esters against oral pathogens," wrote the researchers from the Center for Oral Health Research at U of K's College of Dentistry.
"Most Omega-3 studies on oral health have been focused on the inflammation part; for some reason, the anti-bacterial activity has not mentioned or ignored, including a recent Japanese study. The anti-bacterial part of the omega-3 fatty acids could be very important. Certainly, it could be a potential new use of omega-3 fatty acids as the nutraceuticals in the future," they added.
The new study looked at the effects of EPA, DHA, ALA and their fatty acid ethyl esters, on a range of oral pathogens. All the omega-3 compounds studies were found to exhibit strong antibacterial activity.
The study, sponsored by the US National Institutes of Health, found that the naturally-occurring compounds showed cent 50 per cent inhibitory activity for concentrations ranging from 1 to 10 micrograms per millilitre.
The research work in this area was ongoing and expanding. "Of course, we plan to study and answer those questions about the optimal dosages, pharmacokinetics, the delivery into the oral cavity, and what kind of in vivo dosage/effect to expect, and so on," they noted.
Source: Molecular Oral Microbiology Volume 25 Issue 1, Pages 75 - 80 "A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives"
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