Cardiovascular Health
Heart-Healthy Oats Have Anti-Inflammatory Properties To Protect Arteries
Cooling Inflammation from oat compounds, known as avenanthramides and phenolic antioxidants are recognized as valuable for helping support arteries and cardiovascular health...
Agricultural Research Service (ARS)- funded scientists have reported new reasons for choosing "heart-healthy" oats at the grocery store.
Nutritionists of the Vascular Biology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston, Mass., led the research on the oat compounds, called avenanthramides. The researcher team previously has shown that phenolic antioxidants in oats obstruct the ability of blood cells to stick to artery walls.
Chronic inflammation inside the arterial wall is part of the process that eventually leads to a disorder known as atherosclerosis. The colleagues have reported findings that suggest the avenanthramides of oats decrease the expression of inflammatory molecules. The study showed that forms of avenanthramides possess potential anti-inflammatory properties through inhibiting factors that are linked with activating proinflammatory cytokines.
Cytokines are small proteins released by cells while seeking to protect and repair tissue. Some trigger inflammation, for example, while responding to infection. Inhibiting inflammation through diet, drugs, or key nutrients is considered to be of great benefit in preventing atherosclerosis.
Details of this study can be found in the scientific journal Free Radical Biology & Medicine. The study provides additional indications of the potential health benefit of oat consumption in the prevention of coronary heart disease beyond its known effect through lowering blood cholesterol.
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Cardiovascular Benefits of Dairy Proteins...
Dairy-Souce Proteins, Peptides, Amino Acids Valuable For Helping Support Cardiovascular Health, According to New Reports.
A combination of milk proteins may reduce hardening of the arteries, says a new study from Finland that support the cardiovascular benefits of the dairy peptides.
The combination of isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) were found to reduce arterial stiffness and enhancing the function of the cells lining blood vessels (endothelial cells) in people with hypertension, according to results published in the European Journal of Clinical Nutrition.
About one billion people worldwide suffer from high blood pressure (hypertension), defined as having a systolic and diastolic blood pressure (BP) greater than 140 and 90 mmHg. It is a major risk factor for cardiovascular disease (CVD) - a disease that causes almost 50 per cent of deaths in Europe.
The results fit with wider heart health benefits of the ingredients. A meta-analysis from Chinese scientists and published in Nutrition pooled data from the trials showed that the milk tripeptides were associated with a 4.8 mmHg reduction in systolic blood pressure and a 2.2 mmHg reduction in diastolic blood pressure.
Study details...
Researchers from Valio and the Univeristy of Helsinki recruited 89 people with hypertension and randomly assigned them to receive a low dose of tripeptides (5 mg/day) for 12 weeks, followed by a high dose (50 mg/day) for a further 12 weeks, or placebo.
At the end of the study, arterial stiffness, measured as augmentation index (AIx), decreased in the peptide group by 1.53 per cent, while it increased in the placebo group, report the researchers.
On the other hand, no changes in endothelial function were observed between the groups. The researchers note that the action of the peptides may be linked to the angiotensin converting enzyme (ACE)-inhibitory activity. ACE inhibitors work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure.
"Another mechanism that must be considered is the fact that the functional stiffness of the large arteries is affected by the distensive effect that blood pressure exerts on the arterial walls," they wrote.
"Given that both systolic and diastolic blood pressure diminished in the intervention group, AIx reduction could to some extent be explained by lowered blood pressure. In any case, regardless of the underlying mechanism, reduced arterial stiffness is beneficial to cardiovascular health by reducing cardiac after load and central systolic augmentation."
Source: European Journal of Clinical Nutrition Published online "Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects"
